BITS-Pilani Hyd researchers develop transportable sensor to detect triglyceride ranges in minutes

The sprawling Birla Institute of Know-how and Science, Pilani – Hyderabad Campus.
| Photograph Credit score: The Hindu

Researchers at MEMS, Microfluidics and Nanoelectronics (MMNE) Lab, BITS Pilani, Hyderabad campus, have introduced the event of an revolutionary electrochemical biosensor for the speedy and cheaper detection of triglycerides (TGs), an important marker for coronary heart illness danger evaluation, on Monday.

The system goals to rework point-of-care diagnostics by offering sooner and extra accessible TG degree testing, which is linked to elevated dangers of coronary heart assault, stroke, and atherosclerosis, mentioned said principal investigator R.N. Ponnalagu.

It additionally presents promising potential for on-site TG monitoring, considerably enhancing coronary heart illness administration and preventive care worldwide, he mentioned. The biosensor utilises screen-printed carbon electrodes made out of commercially out there overhead projector sheets.

It incorporates gold-cerium oxide nanoparticles to reinforce sensitivity and pace up enzymatic reactions. Lipase, a digestive enzyme that breaks down fat in meals for absorption within the intestines, is immobilised on the electrodes to hurry up reactions with TG, producing {an electrical} present that’s proportional to the focus of TGs.

A typical take a look at electrode is usually priced at roughly ₹10, offering an accessible choice for efficient well being monitoring in comparison with commercially out there one which price round ₹300 to ₹500, Dr. Ponnalagu mentioned. The system is appropriate for real-time monitoring with out pattern pre-treatment and a conveyable read-out system, known as ‘potentiostat’, provides to its practicality in varied healthcare settings, in accordance with analysis scholar Parvathy Nair.

“This platform might significantly help within the speedy detection of TriGlyceride ranges, and we’re actively increasing its capabilities for multiplexed biomarker detection,” knowledgeable co-principal investigator Sanket Goel. “Our biosensor options superior supplies in a conveyable design, making it a game-changer for real-time TriGlyceride monitoring in point-of-care settings,” he mentioned.

Prof. Goel mentioned the analysis staff is working to growing a turnkey prototype and planning to commercialise it by way of their start-up, Pyrome Innovation. The work is anticipated to be offered on the 2025 IEEE Utilized Sensing Convention, scheduled to be held in Hyderabad in January 2025. The work was supported by Semiconductor Analysis Company, USA.

The work was additionally printed within the peer-reviewed journal IEEE Sensors Letters, in its December 2024 situation.